Enantioselective Extraction Of Racemic Amlodipine Using Tartaric Acid Derivatives And B-Cyclodextrin Derivatives As Chiral Selectors
Hairul Nazirahmiddle Abdul Halim
School Of Bioprocess Engineering
Universiti Malaysia Perlis (Unimap)
02600 Arau Perlis
Malaysia
Abstract:
The distribution behavior of amlodipine enantiomers was examined in a two-phase system containing tartaric acid derivatives in organic phase and beta-cyclodextrin derivatives in aqueous phase. The effect of extraction equilibrium time, influence of different alkyl chain of tartaric acids, types of beta-cyclodextrin derivatives and organic solvent were investigated, respectively. It was found that the chiral extraction reaches equilibrium after 6 hours. Solvents showed a large influence on enantioselectivity and partition coefficients.
